Cymbopogon citratus essential oil has hepato/renal protection and anti-genotoxicity against carbon tetrachloride
DOI:
https://doi.org/10.14295/cs.v11i0.3219Resumo
(five consecutive days treatment). Remarkable adverse effects of CCl4 in all the tested parameters were recorded. These effects were distinguished as an increment in the level of all liver marker enzymes (ALT, AST, ALP, γ-GT), blood urea, and creatinine. Also the oxidative stress biomarkers: malondialdehyde (MDA) and glutathione-transferase GST were affected after CCl4 treatment. Regarding to the genotoxic effect of CCl4, the percentage of chromosomal aberrations in bone marrow and spermatocyte cells was elevated (p< 0.05) compared with the negative control. Notable antioxidant, hepato/renal protection and anti-mutagenic potency of CCEO against CCl4 were demonstrated with a dose-related relationship. GC/MS analysis demonstrated the presence of 12 phytochemical constituents which in combination play a critical role in its antioxidant/antigenotoxic efficacy. The major components exist were E. Citral (35.13%) and Geraniol (32.83%).
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